Fifty per cent of survivors had been sacrificed 1 week later, and blood and urine samples had been taken. Resorcinol showed a concentration-dependent increase in labelling index [ 3 H]thymidine , acanthosis, and papillomatosis. After application of an ointment containing To study the goitrogenic activity of resorcinol, feminine Wistar rats have been handled twice day by day for 28 days by rubbing 6 g of an ointment containing Increased thyroid gland weights 2.

British Journal of Industrial Medicine , Toxicologic Pathology , Toxicology and Applied Pharmacology , Arnott DG, Doniach I The effect of compounds allied to resorcinol upon the uptake of radioactive iodine I by the thyroid of the rat. IARC evaluated the carcinogenicity of resorcinol in and concluded that there are not any epidemiological information relevant to the carcinogenicity of resorcinol in people and that the evidence of its carcinogenicity in animals is inadequate; thus, resorcinol isn’t classifiable as to its carcinogenicity to people. JECFA assessed the hazards from using resorcinol as a food flavouring agent and concluded that this use is of no safety concern. Overall, the research aren’t sufficient for a statistical extrapolation approach according to the EU Technical Guidance Document EC, a.

In , medical examinations see above and thyroid assessments were carried out with of presumably energetic plant workers men and 33 ladies. Flaked resorcinol triggered no perceptible to reasonable irritation intact pores and skin or no perceptible necrosis abraded skin.

• Data regarding the totally different job categories weren’t supplied.
• In one examine performed with male Syrian golden hamsters, which targeted only on results on the forestomach, pyloric region, and urinary bladder, the animals were dosed with 0 or zero.
• However, it must be considered that acned skin could also be damaged due both to scratching or to the blemishes themselves.
• In in vitro genotoxicity tests, resorcinol showed principally negative results.
• In addition, male rats have greater circulating ranges of TSH than females.
• There are a number of research obtainable on acute toxicity to completely different fish species.

In in vitro genotoxicity exams, resorcinol showed mostly unfavorable results. Results from all reported in vivo checks for genotoxicity were negative. Mostly unfavorable outcomes had been reported within the initiation—promotion research carried out using several species. UV irradiation triggered no elevated skin reactions. The iodination course of is catalysed by a haem-containing enzyme.

There is not any guideline examine on toxicity for aquatic vegetation out there. As just one focus was tested, the examine can’t be used within the threat analysis. There are a number of studies obtainable on acute toxicity to completely different fish species.
In in vitro human skin studies, resorcinol was evaluated from a representative hair dye formulation that contained 0. However, it ought to be thought-about that acned skin may be damaged due both to scratching or to the blemishes themselves.

In follow, nevertheless, the incidence of sensitization appears to be low. In animal studies, the toxicological effects reported to be brought on by administration of resorcinol embody thyroid dysfunction, irritation to skin and eyes, CNS effects, and altered adrenal gland relative weights. After topical use of excessive concentrations of resorcinol, CNS disturbances, such as dizziness, vertigo, confusion, disorientation, amnesia, or tremors, or red blood cell changes, corresponding to methaemoglobinaemia, haemolytic anaemia, haemoglubinuria, or cyanosis, have been reported. One issue rising potential toxic effects is the application of resorcinol to injured pores and skin.